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apalutamide will lower the extent or impact of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with drugs that happen to be CYP3A4 substrates may lead to lower exposure to these prescription drugs.Some leisure prescription drugs, incl